Marvel has taken their fan-favorite antihero and thrown him into a chaotic, virtual reality landscape. But this time around, they’ve handed over the mic to entertainment’s most versatile talents. Merc with a Mouth will be played by Neil Patrick Harris himself, who is best known for How I Met Your Mother.
The Deadpool VR is already making waves, especially now that Harris is going to voice Wade Wilson. But could he really be better than Ryan Reynolds when it comes to voicing the character? So let’s dive into what makes the VR so great, and how Harris is at the heart of it.
Deadpool VR is a violent and hilarious spectacle

Despite being one of Marvel’s most popular characters, Deadpool hasn’t exactly been a mainstay in video games. But that’s about to change with Deadpool VR, developed by Twisted Pixel. The announcement was made at the Summer Game Fest 2025, with a trailer that looks amazing.
However, the game is designed exclusively for Meta Quest 3, and it brings players into Deadpool’s absurd and meta-fueled world with stylized combat, chaotic missions, and, of course, a truckload of inappropriate jokes! The premise is how the character is forced into Mojoworld and ends up in gladiatorial combat.
As per reports, the game allows you to wield swords, pistols, and katanas. But Deadpool VR isn’t just a gore-fest; it’s a layered and comedic action game with a meta-narrative (via Games Radar). As in, the character knows he is in a video game and pokes fun at everything from tutorial prompts to game design itself.
Neil Patrick Harris is the Deadpool we didn’t know we needed

Now, let’s get the obvious out of the way: Ryan Reynolds is Deadpool! His portrayal has been nothing short of iconic and wildly entertaining. But Neil Patrick Harris? Oh, he’s a different beast when it comes to voice acting, and he’s absolutely killing it in Deadpool VR.
This isn’t his first rodeo with voicing Marvel characters and has even won awards for Spider-Man: Shattered Dimensions. His performance sounds wild, unhinged, and surprisingly nuanced because he captures everything we love about Deadpool. Here’s what Harris spouts off in the trailer:
Oh hi new friend. Oh yeah. Escape the turd burger of late-stage capitalism and enter a world of VR magic and wonder. You’ll care for exotic pets, the elderly, and this thing with hip hop Satan. Oh hi, Don’t worry He’s a fascist He deserves this big time.
It’s hilarious, it’s meta, it’s totally Deadpool, and slightly better than Reynolds, which is saying something! Harris is known for balancing manic energy with emotional beats, and this quality shines through in the trailer. Moreover, his voice doesn’t feel like commentary, but like he’s directly talking to you! Deadpool may have found his new favorite dimension, and we may have found our new favorite Deadpool.
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